I am trying to change how we pay an employee but the direct deposit information I am entering won't give me the option to save?

Hi Rooted:

From Employees/Payroll and clicking Edit beside the Employee Name, then Direct Deposit and Edit beside the account used to pay the employee you should be able to edit their banking details.  If the save option  is greyed out for you it may be you've been setup as a more basic user without rights to make this change.  You should talk to your Quickbooks administrator to review the settings and ensure you have the rights you need to do your job.

Alternatively - as a work around - you can add an additional account to the employee under the Direct Deposit screen, changing the old one to 0%, and the new one to 100% in terms of the Amount field which allows you to deposit payroll into multiple accounts (typically used for garnishments like child support).