I have QB Pro 2018

Thanks for sharing the steps to open QuickBooks Desktop Pro 2018, @Bo 161.

Let me share another troubleshooting steps we can use to open the program and continue with your business. 

Before we proceed, can you share with me the error message you're getting when opening QuickBooks? Any additional info would be much appreciated. 

Since the QuickBooks Tool Hub and Run as Administrator don't work, we can repair QuickBooks to fix all damaged installation files. That way, we can open the software. 

1. Go to Start.
2. Select Control Panel.
3. Under Programs and Features, select Uninstall a Program.
4. Click QuickBooks, and select Uninstall/Change.
5. Select Repair.
6. Click Finish.

In addition, here's an article you can read to learn more about how you can repair QuickBooks: Repair your QuickBooks Desktop for Windows.

If the issue persists, let's run a clean install to fix the problem. Doing this won't affect your data at all. 

Lastly, I've got you these articles for ideas to help manage your account and related tasks: Help Articles for QuickBooks Desktop.

Please let us know about the result of the steps above. We want to make sure to get this resolved for you. I’ll keep an eye out for your reply!