I work from home. Should I mark my rent payment as a business expense each month? Also, my wife also works from home. Should I just split that type?

Nice to have you here in the Community space, @johnwilliamlomba.

If that rent payment is part of your business, then you can mark it as a business expense. Also, if you and your wife are half of the rent, then, you'll only record what you've paid, especially if you both have different business. 

To give you more of an idea about categorizing your Rent and Lease expense, take a look at this article: Categorize home office expenses and enter square footage in QuickBooks Self-Employed.

You can also see this great resource which you may find helpful: Schedule C and expense categories in QuickBooks Self-Employed.

Please let me know if you need anything else. I'll be around to help you some more. Take care.