When entering an invoice from a vendor that contains several line items is it best practice to set-up each line item as a product/service?

Hello there, ctlee. Let me help you manage your vendor bill in QuickBooks Online (QBO).

If all products are the same, you can input 5 in the Quantity column to sum up to $500. If not, you can add a product to each line item. This is to ensure your accounting records are accurate and that future invoices can be entered more swiftly.

Furthermore, you can check out this article to learn more about  adding purchase orders to expenses or bills: Record a bill or expense after your vendor accepts the purchase order.

Feel free to circle back if you still have additional queries about the bill in QBO. I'm always here to help you.